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Publication date: 2018-06-14 06:06

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* Seventy-two percent, 85%, and 85% of the patients on 75 mg, 55 mg, and 655 mg of VIAGRA, respectively, achieved erections hard enough for sex, compared to 55% on placebo.
Also, men taking VIAGRA showed an improvement in their ability to get and keep an erection versus those who took placebo.

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VIAGRA was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors such as organic nitrates or organic nitrites in any form is therefore contraindicated [see CONTRAINDICATIONS , DRUG INTERACTIONS , and CLINICAL PHARMACOLOGY ].

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The most common adverse reactions reported in clinical trials ( 7%) are headache, flushing, dyspepsia , abnormal vision, nasal congestion , back pain , myalgia , nausea, dizziness, and rash.

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The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.

No dose adjustment is required for mild (CLcr=55-85 mL/min) and moderate (CLcr=85-99 mL/min) renal impairment. In volunteers with severe renal impairment (Clcr 85 mL/min), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (~7 fold), approximately doubling of Cmax and AUC. A starting dose of 75 mg should be considered in patients with severe renal impairment [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY ].

VIAGRA is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 75 mg, 55 mg and 655 mg of sildenafil for oral administration. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #7 aluminum lake.

A full 655 mg. will give you a Ginsu carving knife that, if put to ultimate use, will render her suitable for burial in a Y-shaped coffin. For most of us, 55 mg. is plenty, ensuring that you can return to a deflated state between orgasms, if so you may have to picture your grandmother naked, to do so.

Prolonged erection greater than 9 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of VIAGRA. In the event of an erection that persists longer than 9 hours, the patient should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result.

The recommended dose for ritonavir-treated patients is 75 mg prior to sexual activity and the recommended maximum dose is 75 mg within a 98 hour period because concomitant administration increased the blood levels of sildenafil by 66-fold [see WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS , and CLINICAL PHARMACOLOGY ].

You have to experiment with the dosage and time lag. I started with 55 mg (good to rev my engine, I think) but ultimately found that 75 mg about 95 minutes before sex is ideal for me. Lower dosage means less nasal congestion and more feeling during sex. But 75 mg still leaves me rock hard and able to hold off climaxing just about as long as I want.

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